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Lab W |

Lab W fullpage
life decoders

Explore the World & Adventure in Science


ABOUT US

Who Are We

We are a group of scientists from 🏫 ZJU-UoE Institute working on decoding puzzles in bio-medical sciences. Topics we are interested in include epigenetic regulation of transposable elements in stem cells and cancer, genomics technology and bioinformatic algorithm development.
By combining both "wet lab" (experimental 🔬) and "dry lab" (computational 💻) approaches, we hope to provide our unique expertises in advancing our understandings for bio-medical sciences.

RESEARCH

We Are Exploring

Item 1

Epigenetics BEYOND DNA

Epigenetics study the changes of phenotype without changes in DNA sequence.The prefix epi- means "on top of".

Item 1

Transposable Elements THE 'JUMPING' GENE

For decades, scientists dismissed transposable elements, also known as transposons or “jumping genes”, as useless “junk DNA”. But are they really?

Item 1

Genomics & AI DATA-DRIVEN BIOMEDICINE

Nowadays, artificial intelligence (AI) learn to drive cars, play GO, recognize images, transcribe speech and translate text. What AI is capable in genomics?

MEMBERS

Meet Our Team

Wanlu Liu

Wanlu Liu, Ph.D. Principal Investigator

Assistant Professor, ZJU-UoE institute, Zhejiang University

📧 wanluliu@intl.zju.edu.cn 👩🏻‍💻 Personal Homepage @ ZJU
Lingyan Xu

Lingyan Xu Lab Assistant

📧 lingyanxu@intl.zju.edu.cn
Wanlu Liu

Yixin Guo Ph.D. Student,Co-mentored with Dr.Wang Lie

B.Eng., Bioinformatics, Southwest JiaoTong University

📧 yixinguo@zju.edu.cn 👨🏻‍🎓 ZJU-UoE dual PhD programe
Wanlu Liu

Dengfeng Ruan Master Student, Co-mentored with Dr.Shen Weiliang

Major in Clinical Medicine, Zhejiang University

📧 dfruan@zju.edu.cn
Wanlu Liu

Xinyu Xiang Undergradaute Thesis Student

Major in Applied Bioscience, Zhejiang University

📧 xxyxiangxinyu@163.com
Wanlu Liu

Shiqi Xu Undergradaute Researcher

Major in Biomedical Sciences, ZJU-UoE Institute, Zhejiang Univeristy

📧 shiqix.18@intl.zju.edu.cn
Wanlu Liu

Adele Valeria Undergradaute Researcher

Major in Biomedical Informatics, ZJU-UoE Institute, Zhejiang Univeristy

📧 Valeria.18@intl.zju.edu.cn
Wanlu Liu

Kaiwen Luo Undergradaute Researcher

Major in Biomedical sciences, ZJU-UoE Institute, Zhejiang Univeristy

📧 3170111459@zju.edu.cn
Wanlu Liu

Yanran Qiu Undergradaute Researcher

Major in Biomedical Informatics, ZJU-UoE Institute, Zhejiang Univeristy

📧 yanran.18@intl.zju.edu.cn
Wanlu Liu

Hanqi Xie Undergradaute Researcher

Major in Biomedical Informatics, ZJU-UoE Institute, Zhejiang Univeristy

📧 Hanqi.18@intl.zju.edu.cn
PUBLICATIONS

Our Works

*co-first author, #Corresponding author, members of our group are underlined.

2019

23. Lin, F.*, Meng, X.*, Guo, Y., Cao, W., Liu, W., Xia, Q., Hui, Z., Chen, J., Hong, S., Zhang, X., Wu, C., Wang, D., Wang, J., Lu, L., Qian, W., Wei, L., Wang, L.#. 2019. Epigenetic initiation of the TH17 differentiation program is promoted by Cxxc finger protein 1. SCIENCE ADVANCES ,5,eaax1608
21. Potok, M.E.*, Wang, Y.*, Xu, L., Zhong, Z., Liu, W. , Feng, S., Naranbaatar, B., Rayatpisheh, S., Wang, Z., Wohlschlegel, J.E., Ausin, I.#, Jacobsen, S.E.#, 2019. Arabidopsis SWR1-associated protein methyl-CpG-binding domain 9 is required for histone H2A. Z deposition. Nature communications ,10(1), p3352
20. Nohales, M.A., Liu, W., Duffy, T., Nozue, K., Sawa, M., Pruneda-Paz, J.L., Maloof, J.N., Jacobsen, S.E.# and Kay, S.A.#, 2019. Multi-level Modulation of Light Signaling by GIGANTEA Regulates Both the Output and Pace of the Circadian Clock. Developmental cell, 49(6), pp.840-851.
19. Gallego-Bartolome, J.*, Liu, W.*, Kuo, P.H., Feng, S., Ghoshal, B., Gardiner, J., Zhao, J.M.C., Park, S.Y., Chory, J. and Jacobsen, S.E.#, 2019. Co-targeting RNA polymerases IV and V promotes efficient de novo DNA methylation in Arabidopsis. Cell, 176(5), pp.1068-1082.
18. Papikian, A., Liu, W., Gallego-Bartolomé, J. and Jacobsen, S.E.#, 2019. Site-specific manipulation of Arabidopsis loci using CRISPR-Cas9 SunTag systems. Nature communications, 10(1), p.729.
17. Stoddard, C.I., Feng, S., Campbell, M.G., Liu, W., Wang, H., Zhong, X., Bernatavichute, Y., Cheng, Y., Jacobsen, S.E.# and Narlikar, G.J.#, 2019. A Nucleosome Bridging Mechanism for Activation of a Maintenance DNA Methyltransferase. Molecular cell, 73(1), pp.73-83.

2018

16. Chen, D.*, Liu, W.*, Zimmerman, J., Pastor, W.A., Kim, R., Hosohama, L., Ho, J., Aslanyan, M., Gell, J.J., Jacobsen, S.E. and Clark, A.T., 2018. The TFAP2C-Regulated OCT4 Naive Enhancer Is Involved in Human Germline Formation. Cell reports, 25(13), pp.3591-3602.
15. Harris, C.J.*, Scheibe, M.*, Wongpalee, S.P., Liu, W., Cornett, E.M., Vaughan, R.M., Li, X., Chen, W., Xue, Y., Zhong, Z. and Yen, L., 2018. A DNA methylation reader complex that enhances gene transcription. Science, 362(6419), pp.1182-1186.
14. Pastor, W.A., Liu, W., Chen, D., Ho, J., Kim, R., Hunt, T.J., Lukianchikov, A., Liu, X., Polo, J.M., Jacobsen, S.E.# and Clark, A.T.#, 2018. TFAP2C regulates transcription in human naive pluripotency by opening enhancers. Nature cell biology, 20(5), p.553.
13. Liu, W.*, Duttke, S.H.*, Hetzel, J., Groth, M., Feng, S., Gallego-Bartolome, J., Zhong, Z., Kuo, H.Y., Wang, Z., Zhai, J., Chory, J., Jacobsen, S.E.#, 2018. RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis. Nature plants, 4(3), p.181.
12. Gallego-Bartolomé, J.*, Gardiner, J.*, Liu, W.*, Papikian, A.*, Ghoshal, B., Kuo, H.Y., Zhao, J.M.C., Segal, D.J. and Jacobsen, S.E.#, 2018. Targeted DNA demethylation of the Arabidopsis genome using the human TET1 catalytic domain. Proceedings of the National Academy of Sciences, 115(9), pp.E2125-E2134.
11. Zhang, Y.*, Harris, C.J.*, Liu, Q.*, Liu, W., Ausin, I., Long, Y., Xiao, L., Feng, L., Chen, X., Xie, Y., Chen, X., Zhan, L., Feng, S., Li, J.J., Wang, H.#, Zhai, J.#, Jacobsen, S.E.#, 2018. Large-scale comparative epigenomics reveals hierarchical regulation of non-CG methylation in Arabidopsis. Proceedings of the National Academy of Sciences, 115(5), pp.E1069-E1074.

2017

10. Clark, A.T.#, Gkountela, S., Chen, D., Liu, W., Sosa, E., Sukhwani, M., Hennebold, J.D. and Orwig, K.E., 2017. Primate primordial germ cells acquire transplantation potential by Carnegie stage 23. Stem cell reports, 9(1), pp.329-341.
9. Chen, D., Liu, W., Lukianchikov, A., Hancock, G.V., Zimmerman, J., Lowe, M.G., Kim, R., Galic, Z., Irie, N., Surani, M.A., Jacobsen, S.E., Clark, A.T.# 2017. Germline competency of human embryonic stem cells depends on eomesodermin. Biology of reproduction, 97(6), pp.850-861.

2016

8. Ausin, I., Feng, S., Yu, C., Liu, W., Kuo, H.Y., Jacobsen, E.L., Zhai, J., Gallego-Bartolome, J., Wang, L., Egertsdotter, U., Street, N.R., Jacobsen, S.E.#, Wang, H.#, 2016. DNA methylome of the 20-gigabase Norway spruce genome. Proceedings of the National Academy of Sciences, 113(50), pp.E8106-E8113.
7. Li, S., Yen, L., Pastor, W.A., Johnston, J.B., Du, J., Shew, C.J., Liu, W., Ho, J., Stender, B., Clark, A.T. and Burlingame, A.L., Daxinger, L.#, Patel, D.J#, Jacobsen, S.E.#, 2016. Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. Proceedings of the National Academy of Sciences, 113(35), pp.E5108-E5116.
6. Harris, C.J.*, Husmann, D.*, Liu, W., El Kasmi, F., Wang, H., Papikian, A., Pastor, W.A., Moissiard, G., Vashisht, A.A., Dangl, J.L., Wohlschlegel, J.A., Jacobsen, S.E.#, 2016. Arabidopsis AtMORC4 and AtMORC7 form nuclear bodies and repress a large number of protein-coding genes. PLoS genetics, 12(5), p.e1005998.
5. Pastor, W.A.*, Chen, D.*, Liu, W.*, Kim, R., Sahakyan, A., Lukianchikov, A., Plath, K., Jacobsen, S.E.# and Clark, A.T.#, 2016. Naive human pluripotent cells feature a methylation landscape devoid of blastocyst or germline memory. Cell stem cell, 18(3), pp.323-329.

2015

4. Zhai, J.*, Bischof, S.*, Wang, H., Feng, S., Lee, T.F., Teng, C., Chen, X., Park, S.Y., Liu, L., Gallego-Bartolome, J., Liu, W., Henderson, I.R., Meyers, B.C., Ausin, I.#, Jacobsen, S.E.#, 2015. A one precursor one siRNA model for Pol IV-dependent siRNA biogenesis. Cell, 163(2), pp.445-455.

2014

3. Pastor, W.A.*, Stroud, H.*, Nee, K., Liu, W., Pezic, D., Manakov, S., Lee, S.A., Moissiard, G., Zamudio, N., Bourc’his, D. and Aravin, A.A., Clark, A.T.#, Jacobsen, S.E.#, 2014. MORC1 represses transposable elements in the mouse male germline. Nature communications, 5, p.5795.

2013

2. Jiang, Y., Chen, L., Zhang, S., Tong, T., Zhang, W., Liu, W., Xu, G., Tuan, R.S., Heng, B.C., Crawford, R. and Xiao, Y.,Ouyang, H.W.#, 2013. Incorporation of bioactive polyvinylpyrrolidone–iodine within bilayered collagen scaffolds enhances the differentiation and subchondral osteogenesis of mesenchymal stem cells. Acta biomaterialia, 9(9), pp.8089-8098.

2012

1. Zhang, S., Jiang, Y.Z., Zhang, W., Chen, L., Tong, T., Liu, W., Mu, Q., Liu, H., Ji, J., Ouyang, H.W. and Zou, X.#, 2012. Neonatal desensitization supports long-term survival and functional integration of human embryonic stem cell-derived mesenchymal stem cells in rat joint cartilage without immunosuppression. Stem cells and development, 22(1), pp.90-101.
CONTACT US

Get In Touch

Mailing Address

A314, ZJU-UoE Institute,
718 East Haizhou Rd., Haining, Zhejiang 314400, P.R. China
email: wanluliu@intl.zju.edu.cn

通讯地址

A314, 浙江大学爱丁堡大学联合学院
浙江省海宁市海州东路 718 号,邮编:314400
电子邮箱:wanluliu@intl.zju.edu.cn

Thanks for your interest in LabW 😎

We are alwasys looking for motivated and creative researchers specialized in Molecular Biology, Cellular Biology, Bioinformatics, Computer Science, Statistics and Engineering to join us.

If you are interested in being part of the Lab W, please send your CV and a short research interests to wanluliu@intl.zju.edu.cn

Positions available are : postdocs, graduate students, research assistants , undergraduate research interns.